Oxyntix Ltd Spun-out of the University of Oxford by Isis Innovation with £1m Funding

Oxyntix Ltd, a new company spun-out from the Department of Engineering Science at the University of Oxford by Isis Innovation Ltd., has completed an investment round of £1m.
Scientists at Oxford University are proposing a new method of achieving extreme intensity bubble collapse. This technology has numerous potential applications, notably in nuclear fusion power generation and in sonochemistry, among others. Using state-of-the-art computational simulation techniques, descriptions of unprecedented detail and insight for into the collapse events have been achieved. These have led to the discovery of processes and devices allowing for the control and intensification of the collapse. Oxyntix Ltd has been established to allow development and validation of the Oxford team’s existing research findings, which are already patent-protected.
http://www.isis-innovation.com/news/news/OxyntixLtdspunoutwith1mfunding.html

New Oxford Technology Profiles
 
Isis commercialises technology and research opportunities from Oxford; these are some current examples:
New treatment for breathing disorders
Deep Brain Stimulation technology for treatment of respiratory disease.

3D power doppler ultrasound visualisation
Software and methods for standardisation and measurement of properties at a 3D interface or surface.

Bipolar disorder drug candidate
A drug repurposing candidate for the treatment of bipolar disorder that, unlike current therapies, does not cause any severe side effects.

Antigen identification
Protective antigen-finding technology for the rapid development of new vaccines.

Protein structure determination
High throughput protein structure determination using DNA templates.

Peptide prediction software
An automated tool for understanding the interaction of peptides with the membrane, using course grained molecular dynamics techniques.

Tissue culture incubation
A new design of tissue culture incubator for high precision experiments, allowing maximum control over the chamber conditions.

‘Stampy’ algorithm software
A statistical algorithm for sensitive and fast mapping of Illumina sequence reads.

Scalable acoustic separator
High-throughput, scalable acoustic separator. Platform technology capable of separating particles in suspension with different acoustic properties.

Isopeptide protein tagging From flesh-eating bacteria to protein superglue.
 
Stay on top of the latest University of Oxford innovations by registering for the Isis Technology Update email.  

Investment Opportunities in Technology

Microscopy Software Suite
A suite of software for processing scanning transmission electron microscopy (STEM) images.

Adenovirus: Vector Improvements Two improvements to standard adenovirus vectors which address different challenges in gene delivery and expression.
Measuring Metres Down to the Micron – Absolutely
A fast absolute distance measurement system with superior precision and accuracy.

Reducing Multiple Pregnancies with IVF
A tool which quantitatively grades human embryos to provide high pregnancy rates with low risk of triplets.

Realtime Database Linkage
Software for a high-performance record linkage algorithm, suitable for real-time linkage of large numbers of records.

Analysing the Neurobiology of Learning and Memory
An automated system for evaluating learned behaviour of individual Drosophila (a type of fruit fly), as a novel approach towards identifying mechanisms and compounds for treatment of human memory disorders.

Imaging Detectors for High Performance Applications
New direct detectors – with improved efficiency, contrast and frame rates for imaging and diffraction in Transmission Electron Microscopy (TEM).

Bone Tissue Model3D in vitro bone tissue devices and methods for use in musculoskeletal tissue engineering and regenerative medicine.
Electrochemical Detection of Silver Nanoparticles A fast and simple method to identify, quantify and characterise silver nanoparticles in a sample.
Kit4contactProbabilistic software for predicting disease transmission by animal contact under environmental constraints.
High Throughput Surface Tension Measurement
A rapid, quantitative method for measurement of surface tension in 96-well microtitre assay plates – enables accurate, multiple sample measurements in seconds.

Nucleic Acid Adaptor Technology
Nucleic acid adaptors that significantly lower the cost of fluorescent assays and reduce the time required to develop a fluorescent assay for new targets.

Automated Bioreactor
Automated bioreactor with an incorporated air-driven pneumatic micropump for in vivo-like monolayers and 3D cell culture.
Advances in Scanning Confocal Electron Microscopy (SCEM) A lower cost SCEM giving superior depth resolution.
ERiskMapper Software
User-friendly software for predictive mapping of species and disease distributions and abundances, with applications in conservation and biodiversity research
WWW.ISIS-INNOVATION.COM/LICENSING

Fast Pyrolysis for Bio-fuels Technology
Technology Source: Aston University, UK. The Bioenergy Research Group (BERG) is involved in a £1.4m project to transform bio-oil into a more efficient source of renewable energy, potentially capable of replacing fuels such as diesel.

Magnetocardiogram (BCG)-Based Heart Screening Device
Technology Source: Institute for Cybernetics, Kiev, Ukraine. A fast, accurate, fully non-invasive early stage diagnostics and monitoring solution for cardiovascular diseases.
Pelvic Binder Device
Technology Source: Universiti Kebangsaan Malaysia.
A new design of Pelvic Binder (BRIM) has been develo
ped by doctors at UKM in response to a pressing need for a practical and affordable device. 




Distressed debt Investors

Vulture Investors or Saviours in the Downturn?

International market for distressed debt volume – defined as the acquisition of non-performing and high-default risk liabilities – is today estimated at more than 3.2 trillion US dollars. In Germany distressed debt investing did not become known until the beginning of this century, when market players like Lone Star and Cerberus came onto the scene. The market did not grow by far as fast, however, as projected at the time. Now all of us are looking again at America. (Jens Alsleben, PriceWaterHouseCoopers, Financial Yearbook Germany 2009, pp30)

Because of the preent developments on financial markets emanating from the US many market actors also expect a big wave of distressed debt in this country that will hit the markets in coming months. Besides the cyclical downturn, which has meanwhile been confirmed by well known economic research institutes, it is not least the excessive LBO financigs of recent years that are responsible for this development. As early as Jan 2008 a survey of 100 fund managers revealed expectations of the greatest opportunities ofr Great Britain, Eastern Eurrope and Germany

Where should you look for money to start a business?

when you do need money to start a business, where should you look? Venture capital, private investors, or a bank?

Maybe none of the above. Here’s why.
Research shows that over 90 percent of new ventures start with whatever money entrepreneurs can scrounge from personal resources. The other 10 percent relied on external sources with family members (parents and spouse) as the most common (5.0 percent). Private investors fund less than 3 percent of startups. Venture capitalists are involved in less than 1 percent.

Venture Capital

Why aren’t VCs involved in more startups? Because they’re looking for 30-50 percent return on investment and want to cash out in three to seven years. There aren’t very many startup companies that can present a strong enough management team and good enough marketing strategy to convince a venture capitalist they can do that. (Notice I didn’t mention anything about a wizbang product. Product ideas are a dime a dozen. VCs invest in people and markets.)
But your business is unique, you say, and you think it could be one of 0.6 percent of new business that is able to attract venture capital. You’ll be looking for money in the wrong place if you aren’t in biotech, medical, software, energy and located in Silicon Valley, New York, or New England. In 2009, that’s where almost two-thirds of all VC investments went. In any case, only 9 percent of VC dollars and only 11 percent of the deals went to startup businesses. Your team and your market will have to be very special to attract venture capital. A proposal to fund the development of a chain of Midwest environmental services companies (septic tank cleaners) just won’t interest a venture firm, although they might get a chuckle from your proposal if your slogan is “We want your stinkin’ business” or “Your Poo Is Our Bread and Butter.” (Both are tag lines for real companies.)
So why do people always think of VCs as a source of startup funding? I suspect it’s because they have the mistaken impression that it’s free money. But, of course, it isn’t; you exchange part of your ownership in the company (and some control) for their investment.
I tried to interest a venture firm in an electronic publishing business I’d started. We’d created some innovative software by bootstrapping (using our own time and money), managed to get the product out the door with excellent reviews, and had some impressive names on our customer list. But we needed money to grab an early share in what we knew would be a rapidly growing segment we’d proven existed. I was thrilled when, after careful consideration, they offered the money we need with a 95/5 split. Thrilled, that is, until I realized I was the one who would own 5 percent of the business. I should have paid closer attention to their mascot in the lobby — a stuffed vulture.
Private Investors
Knowing we weren’t destined for explosive growth, when I needed money to start an aviation-related software company, I didn’t look to VCs. I talked to local angel investors, bought a lot of dinners, made a lot of pitches, kissed a lot of frogs, and finally found a lead investor. He was an entrepreneur who’d built an electronics manufacturing business himself. As a pilot, he understood our market. He thought he could convince some people who had invested in his business into investing in mine if I would give up 51 percent ownership. He did, they did, and I did. Ya do what ya gotta do. The company is still in business, although I have no financial interest in it now.
Seven out of 10 private investments are made within 50 miles of an investor’s home or office. Nine out of 10 Angels, as they’re called, put money into small companies with fewer than 20 employees. They’re older, have higher incomes, and are better educated than the average citizen, yet they usually aren’t millionaires. Private investors expect about 25 percent annual return, but in 2009 their investments produced only a 15 percent yield.
You’ll be looking for money in the wrong place with private investors if you don’t have sufficient growth potential, reasonably priced equity, management talent, and an impressive team of key people. But you’ll be happy to know that there’s plenty of informal capital available. Investors say they would invest almost 35 percent more if acceptable opportunities are available.
Banks
If VCs or private investors aren’t an option, what about a loan? If you need one, SBA lenders are your best choice for startup loans. Uncle Sam — who prints the money, after all — guarantees up to 90 percent of your loan so banks are more willing to lend to chancy startups.
In 2009, startup loans guaranteed by the SBA teetered near record lows, down 40 percent from 2007. In any event, 15,000 new companies did manage to get a bank to say yes with the help of an SBA guarantee. Thanks to American Reinvestment and Recovery Act (ARRA) initiatives, the first quarter of 2010 shows SBA loan volume up 90 percent over 2009.
So, what does it take to qualify for an SBA loan? Most lenders will want you collateral with a value at least equal the amount of the loan; and if you own real estate, they’ll want it pledged on the loan. Don’t go looking for loans if you (and your spouse) aren’t willing to personally guarantee the loan. They’ll also want to see projected cash flow (from the business or a secondary source) that comfortably covers the loan payments. Don’t quit your day job!
MDFF
Which leads us back to The Bank of MDFF (Mom, Dad, Friends, and Family). People who know you, like you, or love you will be your most likely source of startup financing. With conventional investment returns in the low single digits, you might just find MDFF eager to lend you money at Prime-plus.
Just keep in mind that taking money from friends is a good way to make them ex-friends. We even know someone who has an ex-brother — the result of a business squabble. As with all things financial, proceed with caution. Finding money is an art, but it is an art you can learn.

Tom Harnish is a serial entrepreneur.